Excessive dietary protein may increase atherosclerosis risk
Consuming over 22% protein daily may clog your arteries
image for illustrative purpose
New York: While eating protein is essential for good health, US researchers have discovered a molecular mechanism by which excessive dietary protein could increase atherosclerosis risk.
Atherosclerosis is the build-up of fats, cholesterol and other substances in and on the artery walls.
The study, which combined small human trials with experiments in mice and cells in a Petri dish, showed that consuming over 22 per cent of dietary calories from protein can lead to increased activation of immune cells that play a role in atherosclerotic plaque formation, driving the disease risk.
Furthermore, the scientists showed that one amino acid -- leucine -- seems to have a disproportionate role in driving the pathological pathways linked to atherosclerosis, or stiff, hardened arteries.
"Our study shows that dialing up your protein intake in pursuit of better metabolic health is not a panacea. You could be doing real damage to your arteries," said Babak Razani, Professor of cardiology at University of Pittsburgh School of Medicine.
"Our hope is that this research starts a conversation about ways of modifying diets in a precise manner that can influence body function at a molecular level and dampen disease risks," Razani added.
The findings are published in the journal Nature Metabolism.
